Farzana Yasmin, Darakhshan J Haleem, Haleem M A.
Effects of repeated restraint stress on serum electrolytes in ethanol-treated and water-treated rats.
Pak J Pharm Sci Jan ;20(1):51-5.

The present study was designed to evaluate the effects of simultaneous ethanol administration (10%, v/v), and restraint stress (2hrs/day for 5 day) on serum electrolytes. This restraint stress decreases serum concentration of Na+, K+, Ca2+, phosphorus, and chloride. Ethanol treatment also decreased Na+, K+, Ca2+, phosphorus, and chloride concentration. The decrease in Ca2+ and phosphorus levels was greater for ethanol-treated restrained than water - treated restrained rats. Ethanol did not affect serum Mg2+ while it was increased in restrained water-treated rats. Ethanol-treated restrained rats exhibited less serum Mg2+ than ethanol-treated unrestrained or water-treated restrained rats. Possible mechanism involved in restraint or ethanol-induced changes of electrolytes is discussed. In conclusion, the result of this study suggest that alteration of serum electrolyte caused by repeated restrained in water-treated and ethanol-treated rats could possibly occur due to an increase in sympathetic activity leading to enhanced excretion of these electrolytes.

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