Hamamatul Bushra Khar, Khawar Sohail, Rizwan Alam, Mohammod Khurram, Azra Khanum, Mian M Arshad, Muhammad Umar, Mohammad Hassan, Khushnood Ahmed, Hamayun Rasheed, Babar Saleem.
Helicobacter pylori genetic profile of dyspeptic patients: perspective from Rawalpindi, Pakistan.
Pak J Gastroenterol Jan ;20(1):6-10.

Toxin related genetic profile of helicobacter pylori has been worked in our circumstances. This cross sectional observational study was conducted at Medical Unit of Rawalpindi Medical College, Rawalpindi in collaboration with Department of Genetics, Arid University, Rawalpindi from January to November 2005 to note CagA positivity and VacA, Helicobacter pylori (HP) allele profile of patients th dyspepsia and urea breath test positivity. Fifty two adult patients were i ucted. Upper gastrointestinal (GI) endoscopy in each case was performed in a standard way. Endoscopic diagnosis of various upper GI diseases were made according to accepted criteria. Endoscopic biopsies were performed in each patient which were processed for DNA extraction, and amplification of selected genes of HP. Data obtained was analyzed using SPSS-10. Of the 52 patients 57.7% (n=30) were male and 42.3% (n=22) female. 15.4% (n=8) patients were CagA positive. s1b/m2, VacA type was most frequently (65.4%, n=34) noted. Other VacA types included s2m2 (7.2%, n=9), s1a/m1 (15.3%, n=8), and slc/m2 (1.9%, n=1). Antral gastritis was commonest endoscopic diagnosis (55.8%, n=29) followed by normal findings (19.2%, n=10). It can be concluded from this study that HP from dyspeptic patients in our scenario are frequently slb/m2, VacA positive, and CagA negative.

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