Mohammad Akram, Mubashir Hussain Cheema, Sherjeel Sana, Zeba Aziz.
Hodgkin`s Disease: Analysis of 75 Patients.
J Coll Physicians Surg Pak Jan ;11(11):702-5.

Objective: To evaluate patients suffering from Hodgkin`s disease to identify its epidemiological characteristics, modalities of treatment and features of survival. Place and Duration of Study : The study was conducted between July 1997 to June 1999 at the Oncology Department of Jinnah Hospital, Lahore. Subjects and Methods : A total 75 patient with Hodgkin`s disease underwent cotswold staging classification, complete hematological, renal and hepatic profile, LDH and uric acid. Chest radiograph abdominal and pelvic ultrasonography and CT scan / MRI bone marrow biopsies. All the patients received combination chemotherapy. Patients with bulky disease received field ratiation. Results: Median age was eight (<18 years) and 26 (>18 years). Male to female ratio was 3.5:1, advanced disease accounted for 68%, mixed cellularity was documented in 61 % of patients. Eighty-two percent of patients belonged to lower socioeconomic strata. Forty-six patients (65.4%) achieved complete remission (CR) Major toxicities were hematological with febrile neutropenia in 14.6% patients. OS of patients achieving CR with good socioeconomic status was superior compared to patients with lower socioeconomic status (p<0.02). Treatment delays were due to economic constraints, illiteracy, malnutrition and co-morbid conditions. Conclusion: Advanced disease, mixed cellularity and male predominance was common. Socioeconomic status had a significant impact on the presentation of the disease. Poor tolerance to chemotherapy and enhanced toxicities are especially seen in the low socioeconomic group.

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