Rezvanieh Salehi, Azin Alizadeh Asl, Mahasti Alizadeh, Manijheh Sayyahmelli, Rasoul Azarfarin.
Comparison of antiphospholipid antibodies in hypertensive with normotensive pregnant women.
Rawal Med J Jan ;32(2):173-5.

Objective: The aim of this study was to assess the association between the occurrence of hypertension (HTN) in pregnancy and antiphospholipid antibodies. Methods: We conducted a cross-sectional study of 100 pregnant women with their first pregnancy induced HTN and no history of thrombosis, renal disease or systemic autoimmune diseases. HTN was defined as blood pressure (BP) of 140/90 mmHg or higher on two measurements with 6 hours apart. Control group comprised of pregnant women without hypertension or proteinuria and without history of thrombosis or systemic autoimmune disease. Antiphospholipid Antibodies (Antiphospholipid IgG and IgM and anticardiolipin IgG and IgM) levels were measured in both groups. Results: There were significantly higher titer of Antiphospholipid IgG and anticardiolipin IgG and IgM in case group (p<0.05). Antiphospholipid IgM had no difference between two groups (p=0.14). There were moderate but statistically significant correlation between blood pressure and parity (r=0.3; p=0.0001), gestational age and antiphospholipid IgM antibody level (r=0.3; p=0.02), and between gestational age and anticardiolipin IgM antibody level (r=0.28; p=0.002). Conclusion: We found elevated levels of IgG and IgM anticardiolipin and IgG antiphospholipid antibodies in pregnancy induced HTN, but level of antiphospholipid IgM antibody was not different in hypertensive and normotensive women. (Rawal Med J 2007;32:173-175).

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