Faris Q Alenzi, Mohammed W Al Rabia, Badi Q Alenazi, Abdulla M Mubaraki, Mahmoud Lotfy, Mohamed Labib Salem, Haris M Siddiqui, Jamal M Arif, Shamweel Ahmad, Ali A Al Jabri, Richard K Wyse.
Role of CTLA-4 in xenotranplantation.
Pak J Physiol Jan ;5(2):40-5.

The replacement of diseased organs by transplantation is now an important medical therapy. However, transplantation is limited by organ shortage. One solution to this problem is xenotransplantation, in other words, the use of organs from animal donors. Although the problem of hyperacute rejection is now largely solved, there is evidence that xenografts suffer other forms of rejection, one of them being T cell response. Moreover, evidence suggests that the degree of immunosuppression required to prevent T cell mediated xenograft rejection will be higher than that needed to prevent T cell mediated allograft rejection. Thus, strategies for graft-specific immunosuppression and improved tolerance are needed, and are discussed in this review. (Review article).

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