Rubina Nazli, Muhammad Rasul Jan, Jasmin Shah, Tasleem Akhtar, Jamilur Rehman, Mudassar Ahmad Khan.
Changes in lipoprotein concentration in primiparous women with pregnancy induced hypertension.
Pak J Med Res Jan ;48(4):83-7.

Background: Pregnancy induced hypertension is a multi system disorder of pregnancy and is a major cause of maternal morbidity and mortality worldwide. Objectives: To evaluate changes in serum lipoproteins in primiparous women with pregnancy induced hypertension and compare it with pregnant women having normal blood pressure. Patients and Methods: This cross sectional study was conducted in 120 pregnancy induced hypertension cases and 21 normotensive pregnant women at gestational age of >20 weeks. History of each woman was recorded on a questionnaire. Height, weight and blood pressure was measured using standard methods. About 5 ml of venous blood was drawn for the analysis of lipoproteins. The data was analyzed using computer software package SPSS version 10. The P Value <0.05 was statistically significant. Results: Mean age of hypertensive cases was 23.7 + 0.42 years while that for controls was 23.9 + 1.16 years. Significant differences were found in serum high density lipoprotein-cholesterol (P <0.001), very low density lipoprotein-cholesterol (P <0.05), triglycerides (P <0.01), total cholesterol/high density lipoprotein-cholesterol (P <0.001), serum triglycerides/high density lipoprotein-cholesterol (P <0.0001), high density lipoprotein-cholesterol/very low density lipoprotein-cholesterol ratio (P <0.0001) and apolipoprotein A1 level (P <0.001) among the groups. However, no significant difference (P >0.05) was noted in total cholesterol, low density lipoprotein-cholesterol, apolipoprotein B100, high density lipoprotein/ apolipoprotein A1 and low density lipoprotein / apolipoprotein B100 ratio in women with pregnancy induced hypertension and normotensive pregnant women. Women who developed pregnancy induced hypertension had 28.8%, 29.5%, 31.1%, 32.9% and 65.3% significantly higher, low density lipoprotein-cholesterol, triglycerides, total cholesterol/high density lipoprotein-cholesterol ratio, low density lipoprotein-cholesterol/high density lipoprotein-cholesterol ratio and triglycerides/high density lipoprotein-cholesterol ratio respectively than the controls. The high density lipoprotein-cholesterol concentrations, high density lipoprotein-cholesterol/very low density lipoprotein-cholesterol ratio and apolipoprotein-A1 were 26.9%, 56.6% and 27.9% respectively lower in women with pregnancy induced hypertension than in controls. Conclusion: This study suggests that evaluation of lipoprotein concentrations during antenatal period can be helpful in the early detection and prevention of pregnancy induced hypertension.

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