Muhammad Arif, Zafar Iqbal, Ziaul Islam.
Serum and aqueous lactate dehydrogenase ratio in the diagnosis of retinoblastoma.
Pak J Med Res Jan ;49(4):124-6.

Background Leakage of lactate dehydrogenase hormone from malignant tumors cells has been described. Objectives: To measure the serum and aqueous lactate dehydrogenase ratio as diagnostic indicator for retinoblastoma. Study type, settings and duration: Prospective analytical study, carried out at Khyber Teaching Hospital Peshawar between 1st July 1999 and 31st December, 2003. Patients and Methods Hundred newly diagnosed patients with retinoblastoma were registered for treatment. The aqueous lactate dehydrogenase was determined in fourteen randomly selected retinoblastoma patients, classified as advanced stage VB group (Rees-Ellsworth classification). Samples from aqueous of these patients were analyzed for lactate dehydrogenase level using automatic scanner (Selectra XL, vital scientific Netherlands). Results The Aquous lactate dehydrogenase was determined in 14 patients, who had a mean age of 36 months (range 2 months – 7.5 years). There was equal number of unilateral and bilateral cases. Mean serum lactate dehydrogenase level was 730 i.u/litre and aqueous lactate dehydrogenase was 27,042 i.u/litre. Serum: aqueous lactate dehydrogenase ratio was 27:1 against normal ratio of 1 to 1. Conclusions: Aqueous lactate dehydrogenase levels were proved to be sensitive biochemical test for supporting the diagnosis of retinoblastoma.

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