Batool Mutar Mahdi, Riyadh Mohamad Hassan, Basma Maki, Nahla Ghanim, Leen Ghalog.
Atrophic gastritis by helicobacter pylori and antiparietal antibodies.
Rawal Med J Jan ;36(2):74-8.

Objective:- To determine if atrophic gastritis is caused by H pylori and anti parietal antibodies. Patients and Methods:- A total of 60 atrophic gastritis patients had their blood analyzed for CagA antibodies IgG and parietal cell antibodies using an indirect immunofluorescence technique. C-reactive protein (CRP) was also measured. Results:- Mean age of patients was 45.67±15.54 years. In 37 (61.6%) patients, H pylori Cag A antibody IgG was positive and in 23 (38.3 %) anti parietal cell antibody was positive (p=0.011, OR and relative risk 1). In 39 (65%) patients, atrophic gastritis was seen only in the antrum; 74.3% of them had H pylori Cag A antibody IgG positive, while 25.6 % had anti parietal cell antibody positive (p=0.000). All atrophic gastritis patients showed positive CRP. Conclusions:- H. pylori infection can exist with autoimmune gastritis leading to cross reactive gastric T cells activation via molecular mimicry. (Rawal Med J 2011;36:74-78).

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