Muzamil Shahzad, Amer Iqbal, Azmat Khan.
Efficacy of amlodipine, tolerability, toxicity and treatment of essential hypertensive patients.
Pak J Med Health Sci Jan ;4(2):89-92.

To find out the efficacy and tolerability of Amlodipne in the treatment of mild to moderate hypertension. It is a case series and observational study carried out in the Department of Medicine at Social Security Hospital, Lahore during the period of seven months from 01-01-2009 to 31-07-2009. Eighty patients included in this study between 30-90 years of age with mean±SD 62.27±8.19. After the taking history they were diagnosed of mild to moderate hypertension and taking antihypertensive medicines but they were not adequately controlled the hypertension. It was defined as diastolic blood pressure between the range of 90-112mmHg in the sitting position. It is based on two different occasions separated by at least 6 days. The dose of Amlodipine 5mg was advised and given on daily basis at least 15 days. The daily dose was titrated upward to 10mg after two weeks, in those patients who did not show satisfactory reduction in blood pressure in the absence of clinically significant side effects, thought to be drug related. Patients were followed up for six weeks on outpatient basis. Results: After the treatment of 6 weeks of patients, the reduction in systolic blood pressure was 30mmHg and reduction in diastolic blood pressure was 20mmHg. Fifty nine (76%) of these patients required 5mg while remaining 19 (24%) needed 10mg of Amlodipine. Patients did not show any significant change in heart rate at the end of the study. Over all assessment of efficacy was excellent in 78%, good in 18%, fair in 4%. As far as toleration was concerned, it was excellent in 81%, good in 15%, fair in 3% and poor in 1%. Out of 80 (14%) patients experienced adverse effects and 2 (3%) were withdrawn from the study due to adverse effects, one male patient after 2 weeks and the other one is female after 4 weeks. Conclusion: This study concluded that Amlodipine is an effective once daily treatment of mild to moderate hypertension.

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