Ayesha Maqbool, Tahir M, Ansa Rabia.
Postmortem study to evaluate age related angiopathy in memory associated brain regions.
Pak J Med Health Sci Jan ;4(1):35-40.

Objective: The present study reveals amyloid deposition in the brain parenchyma. Design: It is cross sectional descriptive study. Place and Duration: The study was conducted in the Department of Anatomy, University of Health Sciences, Lahore. The duration of the study was two years. Methods: Sixty brain specimens (age 19-72 years) of human cadavers were collected using purposive non- probability sampling from the mortuary of the King Edward Medical University, Lahore. Human cerebrums obtained from autopsy table; were divided into two groups according to their age. Group I comprised of deceased less then sixty years of age, group II contains above sixty years of age. The study was confined to those areas of brain which are concerned with memory i.e. cerebral cortex and hippocampus. The microscopic slides were prepared from the cerebral cortex and hippocampus. The prepared slides were stained with Haematoxylin and Eosin and Congo red stains; and were observed under light microscope. Results: The results revealed that some degree of amyloid deposition in the superior frontal gyrus, (principally in the layer II and III) but well marked in the hippocampus. Conclusion: It is not surprising that performance on tasks that require information processing in these brain regions decline with age.

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