Khalil Mubin, Sarwat Sultana, Nida Iqbal, Humaira Sharif, Madiha Taufeeq Bawani, Saira Sikandar, Versha Kumar, Farida Habib.
Morphologic and immunophenotypic patttern of non-hodgkin's lymphoma.
J Bahria Uni Med Dental Coll Jan ;1(1):25-8.
Objective: To describe morphologic and immunophenotypic pattern of Non-Hodgkin’s Lymphoma and to estimate the LDH (Lactate dehydrogenase) levels. Materials And Methods: The study was carried out in Bilquees Naz Children Cancer Hospital, Karachi. Sample size was 205 cases of Non-Hodgkin Lymphoma and study design was cross sectional. Entire research was completed in 5 months. The antibodies used included LCA (leukocyte common antigen), PAN-B and PAN-T. Written consent was taken from the parents of the patients. Confidentiality was maintained of their names and addresses. Results: Non Hodgkin’s lymphoma was more in males as compared to females and common age group (41%) was between 7-12 years of age. B- cell non Hodgkin’s lymphoma was more common than T-cell NHL. Burkitt’s lymphoma was found to be the most common type (18%) of non-hodgkins lymphoma. Common primary site of non hodgkin lymphoma was abdomen (34%) followed by neck (11%) and chest (10%). B-cell lymphoma had predilection for abdomen (59%) while in chest, commonest form was T-cell lymphoma (14%). This association was highly significant as p value came out to be 0.00. The most common tumor marker detected was PAN-B (60%). Most of the cases (85%) had abnormally raised lactate dehydrogenase level. The CSF report showed that in 90% of cases the tumor was not metastasized to central nervous system i.e good prognosis. Most of the patients diagnosed were in stage I of the tumor i.e they had good prognosis. Conclusion: Among morphologic pattern, Burkits lymphoma was the commonest one. In most of the patients LDH level was found to be abnormally high. Among phenotype, B-cell phenotype was the commonest one.
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