Muzammil Ahmad Khan, Naureen Aslam, Muhammad Ansar.
Comparative analysis of autosomal and X-linked genes involved in nonspecific cognitive impairment.
Pak J Med Res Jan ;51(1):21-6.

The focus of research on candidate gene identification of recessive non-syndromic cognitive impairment is increasing and to date 19 genes for X-linked and 10 autosomal non-syndromic mental retardation have been reported. The X chromosome has higher proportion of cognitive genes as compared to autosomes; but the presence of 22 autosomes and the origination of X chromosome from autosome during the course of evolution is putting a mark of question on this fact and leads to the hypothesis that the number of autosomal cognitive genes should be higher in number than the genes on X chromosome. The comparative analysis of both sets (autosomal v/s X-linked) of genes revealed significant similarities with respect to their evolutionary conservation, cellular localization, molecular and biological functions, protein domain sharing, subcellular expression profiling in nervous tissues, etc. The results and observation conclude that the knowledge of X-linked cognitive genes can be utilized in a variety of ways to explore more autosomal cognitive genes computationally.

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