Ayesha Ahmed.
Prognostic and therapeutic role of nuclear factorkappa b (nf-kb) in breast cancer.
J Ayub Med Coll Abottabad Jan ;22(3):218-21.

Nuclear Factor- kappa B (NF-kB) is an essential transcription factor that not only modulates cellular responses to stress but also plays a pivotal role in inflammation, immunity, cell cycle growth and survival. NF-kB-regulated genes have been documented to be involved in cellular proliferation and invasion along with tumour related angiogenesis and lymphangiogenesis. Dysregulation of NF-kB associated pathways are seen in multiple malignancies. Its constitutive activation in the clinically aggressive and prognostically poor ER-negative, Her2-neu positive and inflammatory breast cancer could formulate the basis for its evolution as a potential prognostic and therapeutic target.

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