Nasim Ilyas, Sadiq M, Adnan Jehangir.
Hepatoprotective effect of garlic (allium sativum) and milk thistle (silymarin) in isoniazid induced hepatotoxicity in rats.
Biomedica Jan ;27(2):166-70.

Objective: Assessment and comparison of hepatoprotective role of garlic and silymarin in antituberculosis drug (Isoniazid) induced hepatotoxicity. Materials and Methods: Healthy rats weighing 150 – 200g were selected for the study. Rats were divided into four groups, i.e. group A (Control), group B (INH treated group), group C and D serve as experimental groups. The group A received only the normal diet, Group B along with normal diet received the isoniazid (50 mg/kg/day), Group C along with normal diet received the isoniazid (50 mg/kg/day) and Silymarin (200 mg/kg/day), and Group D along with normal diet received the isoniazid (50 mg/kg/day) and garlic (0.25 g/kg/day). Results: On completion of 28 days of treatment blood samples were collected for the assessment of liver function. In group B there was abnormal rise in the levels of biochemical markers (ALT, AST, ALP and Total Bilirubin). In group C the biochemical markers were near normal levels and in group D the levels of biochemical markers were within normal limits. Conclusion: Both the garlic and silymarin have shown the hepatoprotective effect against the Antituberculosis drug (isoniazid) induced hepatotoxicity in experimental animal model.

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