Sajjad Ali Surhio, Muhammad Memon, Rafeen Talpur, Khalid Iqbal Talpur.
Efficacy of nepafenac 0.1% in maintaining mydriasis during phacoemulsification surgery.
J Liaquat Uni Med Health Sci May ;12(2):74-8.

OBJECTIVE: To determine the efficacy of Nepafenac 0.1% eye drops in maintaining mydriasis during phacoemulsification cataract surgery. METHODS: Patients of 40 – 65 years of age undergoing phacoemulsificaton cataract surgery were randomly divided into two groups. One group received Nepafenac 0.1% eye drops and the other group received placebo (Tears Naturale II eye drops). Pre – operatively; all patients received tropicamide 1% eye drops and phenylephrine 2.5% eye drops. The surgery in all the cases was done by the same ophthalmologist; with intra – operative epinephrine in the irrigating solution. The pupil size was measured with caliper at three steps; immediately before the surgical incision (baseline), at the end of phacoemulsification, and at the end of surgery. RESULTS: 60 eyes of 60 patients were included in the study. 30 eyes were in the Nepafenac 0.1% group and another 30 in the placebo group. The mean age of our patients was 54.18 ± 7.49 years. The mean diameter of pupil at end of surgery was 7.65 ± 0.71 mm in Nepafenac group V/s 6.67 ± 0.97 mm in the placebo group (P– Value < 0.001). In the Nepafenac group; the pupil size at the end of surgery decreased by a mean of 0.55 ± 0.51 mm (range 0.00 – 1.50 mm). Meanwhile; in placebo group the pupil size decreased by a mean of 1.05 ± 0.87 mm (range 0.00 – 3.5 mm). This difference was statistically significant (P = 0.009). CONCLUSION: The pre – operative use of Nepafenac 0.1% eye drops was effective in maintaining mydriasis during phacoemulsification cataract surgery.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com