Shaheena, Abdul Wahab Shaikh, Seemen Ghafoor, Azra Saleem.
Correlation of fasting blood sugar and glycated hemoglobin levels with fructose 2,6 bisphosphate levels in immune cells of diabetic patients.
Pak J Med Health Sci Jan ;6(1):9-12.

Objective: To study the effect of fasting blood sugar and HbA1c on fructose 2,6 bisphosphate in diabetics and comparing and correlating the same parameter with control subjects. Material and methods: Two hundred patients with type-II diabetes and fifty control subjects were selected for this study. Fasting blood sugar and glycated hemoglobin were estimated. Fructose 2,6 bisphosphate was estimated and correlated from peripheral blood mononucleocells. Result: Results showed highly significant fructose 2,6 bisphosphate levels in immune cells in diabetic group. A significantly positive correlation of fructose 2,6 bisphosphate with FBS and HbA1c was seen in diabetic group. Conclusion: Higher levels of FBS and HbA1c are associated with increased levels of fructose 2,6 bisphosphate of peripheral blood mononuclear cells in diabetes reduces immunity.

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