Muzamil Shahzad, Amer Iqbal, Rizwan Zafar Ahmad.
To Identify the Role of C-Reactive Protein in Predicting the Response of Thrombolytic Therapy in Acute Myocardial Infarction.
Pak J Med Health Sci Jan ;6(2):433-7.

Objectives: To identify the role of c-reactive protein in predicting the response of thrombolytic therapy in acute myocardial infarction. Study design: Cross sectional study. Setting: Department of Medicine, Nawaz Sharif Social Security Hospital Lahore. Duration of study: This study carried out from February 2011 to January 2012. Subjects and methods: Sixty patients were included in this study. Information of patients like age, symptoms, myocardial infarction distribution, symptoms according their sex, thrombolytic therapy, correlation between CRP-1 and time duration and CRP-2 and time duration. Results: The age range was 37-70 years, most common age group was 51-60 years, 26(43%) patients. Forty (67%) were males and 20(33%) were females. Chest pain, sweating, dyspnea and vomiting were the main symptoms at presentation, among them chest pain and sweating were the most common, 30(50%) patients. Inferior wall MI was the most common, 25(45%) patients. Successful thrombolysis was seen in 39(65%) patients and 21(35%) patients failed to respond. There was significant correlation between duration of symptom onset and plasma CRP levels (P value <0.05). Conclusion: It is concluded that C-reactive protein has prognostic value for outcome of the disease in patients with acute myocardial infarction and plasma C-reactive protein begins to rise 4-6 hours after onset of symptoms in acute myocardial infarction.

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