Seemen Ghafoor, Azra Saleem, Shaheena, Abdul Wahab Shaikh.
Impact of Pregnancy on C-peptide Levels of Type-II Diabetic Women.
Pak J Med Health Sci Jan ;6(2):358-61.

Objectives: The present study proposes to observe the changes in serum C-peptide levels, HbA1c and fasting blood sugar (FBS) levels in pregnant and non-pregnant diabetes mellitus type ΙΙ (D.M) patients and compare these changes. Method: Thirty pregnant women with D.M type ΙΙ were selected for the study. The subjects were evaluated for pregnancy status and presence of D.M and then FBS, HbA1c and serum C-peptide levels were assessed. Results: Results showed significantly decreased (P< 0.001) levels of FBS and HbA1c in pregnant group as compared to non-pregnant group where as serum c-peptide levels were significantly increased (P<0.001) in pregnant group when compared to non-pregnant diabetic group. Conclusion: It is concluded that FBS and HbA1c levels were lowered in pregnant diabetics as compared with non-pregnant diabetics. This lowering is accompanied with increased levels of circulating C-peptide of insulin, suggesting a state of hyperinsulinemia.

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