Mulazim Hussain Bukhari, Samina Qamar, Shahbaz Ahmad Qureshi, Malik Maqsood Anwar.
Histopathological study of Helicobacter Pylori bearing Gastric Biopsies for Gastric Lesions.
Pak J Med Health Sci Jan ;6(3):588-93.

Background: Helicobacter pylori(HP) recently are associated with gastritis, dysplasia and gastric malignancies. The study was conducted to see the histopathological of HP bearing gastric biopsies for evaluate different gastric Lesions Aim: To determine the frequency of H.pylori in patients with gastric complaints and to see the frequency of different morphological changes in gastric biopsies associated with H.pylori infection. Material and Methods: A descriptive cross sectional study was conducted on 760 gastric biopsy specimens collected from gastroenterology of Mayo Hospital Lahore. Biopsies were sent to the pathology lab of King Edward Medical University in 10 % buffered formalin filled containers. The tissues were processed in automatic tissue processor. The sections were stained with routine Haematoxylin and Eosin and Giemsa stain. Results: Of the 760 patients, 527 (69%) were positive for H. pylor and 233 (31%) were negative for H. pylori. The gastric lesions were more common in males’ 337/589:57% as compared to females’ 252/589:43% with a significant difference (p=0.000). The males experienced gastric complaints and dyspeptic symptoms earlier than females (mean age 38.11±16.66 years & 35.81±14.19 years) with a positive association with patient’s age (p<0.05: 95% confidence interval). Histological examination of 760 cases of gastric biopsies revealed acute and chronic gastritis in 89.5% of patients. A significant number of gastric lesions were seen in patients bearing HP, i.e., Intestinal metaplasia (p=0.01), formation of lymphoid follicles (p=0.059), However dysplasia was seen in (15/527; 2.8%) and malignancy (16/527:3%) in patients of gastritis infected with HP at non significant level. However, gastritis and gastric atrophy was seen in both types of gastritis. Conclusion: A significant gastric lesions were seen in biopsies positive for HP as compared to HP free gastritis, however dysplasia and malignancies were non significantly associated with HP bearing biopsies vs HP negative ones.

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