Jawaid Aslam Channa, Khalid Zafar Hashmi, Tahir Shamsi.
Immunophenotypic Subgroup of Acute Lymphoblastic Leukemia.
J Coll Physicians Surg Pak Jan ;12(3):146-8.

Objective: To observe the frequencies of different subgroups of acute lymphoblastic leukemia (ALL). Design: A retrospective observational study. Place and Duration of Study: This study was carried out in the Haematology Department of Dr. Ziauddin Hospital, Karachi from 1996 to 1998. Subjects and Methods: A total of 47 cases, (31 males and 16 females of median age of 34 years) of ALL diagnosed by conventional methods were selected for the study. The samples received were either peripheral blood or bone marrow. The mononuclear cells were separated by Ficoll density centrifugation using histopaque (Sigma diagnostic). The panel of mononuclear antibodies (MAbs) used for classification include; CD19 (Pan-B), CD7 (Pan-T) and CD13 / CD33 (Pan-myeloid). B cell ALL was further classified into CD10+ and CD10-ALL by applying MAbs against CD10 (common antigen). T cell ALL was not further classified. Results: The common ALL (CALL), which is the most frequent type of childhood ALL in western world, is equal to other subgroups of ALL in this study. In the adults, the ALL subgroups other than CALL are common. Apart from this, there is high ratio of TALL in both the age groups. Conclusion: These results highlight the geographical variations in the incidence of ALL. The childhood peak of ALL observed in western world is not seen in this study and ratio of TALL is high.

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