Muhammad Khurram.
Dengue infection in adults: information for the unwary.
J Rawal Med Coll Jan ;17(2):308-13.

Dengue infection is commonest arthropod borne viral infection affecting humans.1 It affects about 100 million persons yearly.2-4 Dengue infection is caused by Dengue virus which is a RNA virus with four serotypes. Bite of female Aedes mosquito primarily transmits the infection. Infection with one serotype confers life long immunity against it and short term against the other serotypes. Infection with other serotypes after the variable immune period causes immune enhancement. T lymphocyte activation, production of cytokine, mainly tumour necrosis factor alpha (TNF-α) and activation of complement system results from immune enhancement. These along with viral factors are considered responsible for the development of bleeding and capillary leakage.5

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