Sikiru Lamina, Shmaila Mustapha Hanif, Chuba Goddy Okoye.
Effects of Exercise on Metabolic Markers and Biomarkers of Inflammation in Hypertensive cases:A Randomized Controlled Trial.
Pak J Med Res Jan ;51(3):87-92.

Background: Hypertension has been hypothesized to be a part of inflammatory disorder and elevated low density lipoproteins or total cholesterol, and reduced high density lipoproteins, increase the risk of coronary events in these patients. Objectives: To determine the effects of exercise (interval training program) on metabolic markers and biomarkers of inflammation in black African men with essential hypertension. Subjects and Methods: A total of 245 male patients having mild to moderate essential hypertension (systolic BP between 140-179 & diastolic BP between 90-109 mmHg) were age and gender matched into experimental and control groups. The experimental group was put to exercise for 8 weeks using interval training (60-79% HR max reserve) program ranging between 45minutes to 60 minutes, while control group remained sedentary. Cardiovascular parameters (systolic blood pressure, diastolic blood pressure) and VO2max, biomarkers of inflammation (C-reactive protein, white blood cell) and metabolic makers (fasting blood sugar), total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein and artherogenic index) were assessed. Analysis of co-variance (ANCOVA) and Pearson correlation tests were used in data analysis. Results: Of 254 subjects, the experimental group had 140 cases whose ages ranged from 58.9±7.3 years) while 114 were controls of similar age. There was significant effect of interval training program on VO2 max, systolic blood pressure, diastolic blood pressure, C-reactive protein, white blood cell, fasting blood sugar, total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein and artherogenic index (p<0.05). Changes in VO2 max significantly correlated with all other variables (p<0.05). Conclusions: Therapeutic role of interval training program in the reduction of blood pressure could be through the suppression of systemic inflammation and abnormal metabolic markers.

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