Abdul Qayyum Ghauri, Nazim Jat, Pir Bakhsh Khokhar, Madina Khan.
Frequency of thyroid carcinoma in solitary thyroid nodule.
Isra Med J Jan ;6(2):90-2.

OBJECTIVE: To determine the frequency of Thyroid Cancer in solitary nodules of thyroid. STUDY DESIGN: A Retrospective descriptive study. PLACE & DURATION: The study was conducted from 1 January, 2000 to 31 May, 2010 at SOMH (Fauji Foundation Hospital) Karachi st st and from 1 July, 2010 to 31 December, 2013 at Al-Tibri Medical College & Hospital, Isra University, Karachi Campus. METHODOLGY: One hundred and ninety consecutive cases of solitary thyroid nodule presented and operated were included in the study. Patients with multi-nodular goiters were not included in the study. Hemi thyroidectomy was done and if histopathology examination revealed carcinoma, then total thyroidectomy was followed. Results for frequency and percentages were calculated and analysed. RESULTS: Out of Total 190 Cases, 61.58% were females and 38.42% were males. Important presenting symptoms were dysphagia (15.26%), palpitations (14.21%), rapid increase in size (13.68%), apart from the nodule (100%) in thyroid gland. Most of the cases were th rd in 4 decade (35.26%), followed by 3 decade (22.63%) of life. Most of the nodules were benign (91.57%) which included adenoma colloid goiter (42.94%) follicular adenoma (36.81%), simple cysts (18.40%). Malignant nodules were 8.42%, which included papillary carcinoma (75%), follicular carcinoma (18.75%) and medullary carcinoma (6.25%). No case of anaplastic carcinoma was found. CONCLUSION: Solitary thyroid nodules are mostly benign and malignant nodules are mostly well differentiated carcinomas.

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