Humaira Zafar, Kiran Tauseef Bukhari, Ishtiaq Ahmed.
A meta analysis review of helicobacter pylori infection the diagnostic and management options.
Isra Med J Jan ;5(1):65-71.

OBJECTIVES: To verify that the H. pylori infection predisposes to acid peptic disorders, and also find out the importance of non-invasive diagnostic approach. Moreover, to judge the need of quadruple therapy i.e. Amoxicillin, Metronidazole, Clarithromycin, and a proton pump inhibitor along with an appropriate duration in order to reduce the emergence of antibiotic resistance. METHODOLOGY: It was a Descriptive study. The data were collected through electronic means from the National and internationally published data by simple random sampling technique. The latest reports published by World Health Organization, Centre for Disease Control were considered for reference. The original and review articles published in different National and International Journals and available online on Pubmed and Medscape were also taken for reference. While some aspects were also searched from other medical related websites and Google. The Selection criteria for this meta-analysis were the data related to positive cases of H. pylori in patients having acid peptic disorders especially diagnosed through serological identification and were managed through quadruple therapy or by three drugs. The Quality criteria for the reference data was made sure through the authenticity of researches and reports published from recognized and indexed medical websites. RESULTS: This Meta-analysis has shown that H.pylori is the leading cause of various acid peptic disorders. The adoption of non-invasive diagnostic approach should be the preferred one, proven to have the sensitivity and specificity of about 98.3% and 95.0% respectively. Moreover a quadruple therapy i.e Amoxicillin, Clarithromycin, Metronidazole, and a Proton pump inhibitor given for at least 7 to 10 days, has proven to be the best management strategies. CONCLUSION: There is a dire need to early/accurately diagnose the infection and adoption of quadruple therapy regimen in order to minimize the emergence of drug resistant cases.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com