Bashar A Hassawi, Mayada I Yalda, Ferwerdin Sh Barzanji.
The significance of the papanicolaou smears in diagnosis of squamous intraepithelial lesion. a cyto histopathological study.
Isra Med J Jan ;5(1):13-7.

OBJECTIVE: To assess the frequency of intraepithelial lesion in Pap smear and to correlate between the cytopathological and histopathological findings this study were done. STUDY DESIGN: A prospective observational study. PLACE & DURATION: From September 2008 to June 2010 at Azadi Teaching Hospital Duhok City. METHODOLOGY: Cytopathological and histopathological analysis of 136 specimens of cervix diagnosed between 2008 and 2010 at Azadi teaching hospital in Duhok city. Initial cytopathological interpretation was performed based on the Bethesda 2001 criteria. Formalin-fixed, paraffin-embedded tissues were reviewed for confirming histopathological diagnosis, presence of atypia, koilocytosis and changes related intraepithelial lesion. RESULTS: The mean age was 36 years. Out of the 136 cases analyzed. Cytologically includes (n=8) 6% cases of high grade squamous intraepithelial lesion (HSIL), (n=17) 12.5% were low grade squamous intraepithelial lesion(LSIL), (n=77) 56.5% were atypical squamous cells of undetermined significance (ASCUS), (n=34) 25% were negative for intraepithelial lesion and malignancy (NILM) . Histopathologically 2 were squamous carcinoma, 6 were CIN2 and CIN3, (n=37) 27.3% were CIN1 and (n= 91) 66.9% were negative for neoplasia. Koilocytosis was observed in 49. CONCLUSIONS: Women with a Pap diagnosis of NILM, ASCUS and LSIL appear to be less likely to harbor a high-grade lesion than those diagnosed with HSIL alone. The association between cytological (NILM & ASCUS) and histopathological findings is variable and does not show that compatibility. This study showed the high frequency of koilocytosis in both cytology and biopsy which may reflects the high incidence of HPV infection.

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