Ali Nawaz Bhurgri, Asmat Kamal Ansari, Nasreen Qazi, Gunesh Kumar.
Lipid lowering effect of atorvastatin in hypertensive dyslipidemic patients receiving enalapril and amlodipine, a comparative study.
Isra Med J Jan ;5(1):50-3.

OBJECTIVES: To compare the lipid lowering affects of Atorvastatin in hypertensive dyslipidemic patients receiving Enalapril and Amlodipine. STUDY DESIGN: Prospective descriptive and comparative study. PLACE AND DURATION: Study was conducted by the Department of Pharmacology LUMHS Jamshoro from 2007 to 2009 at Red Crescent Hospital Hyderabad. METHODOLOGY: One hundred essential hypertensive dyslipidemic patients were enrolled in the study. Study was approved by the ethical committee. After taking written consent patients were divided into two Groups (A and B) each group comprising of 50 patients. Atorvastatin 20 mg was combined to Group A patients at the bed time along with Enalapril 10 mg in the morning and to group B patients at the same time along with 5 mg of Amlodipine in the morning. Lipid profile was done at the base line and after 03 months (at the end of the study). RESULTS: At the end of the study when both groups were compared for the lipid lowering effect of Atorvastatin it was found that serum cholesterol reduced to 184.48 in group A (243.26± base line) and 185.08 ±15.09 mg/dl in group B (240.44±31.5mg/dl base line) p value 0.78, LDL Cholesterol in group A decreased to 111.08+6.13 (243.26±22.70 at the base line) group B the LDL was decreased 104.40±4.37 which is highly significant HDL cholesterol was increased to 33.502±.05 (29.90+2.65 base line) in group A, while in group B it was increased to 33.40±2.09 (29.240 at base line) triglycerides were reduced in both groups and the result were not significant. Results were compared and analyzed statistically by the SPSS version 16. Statistically the result was taken as significant. P value = 0.05 was considered as statistically significant level for all the comparisons. CONCLUSION: There is significant mean change in the LDL cholesterol in group B (Atorvastatin + Amlodipine).

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