Inayat-ur Rahman Abbasi, Amin Uddin Shaikh, Shakir Khan, Zahid Azeem.
Discordance of serum renin level in patients of essential hypertension and its correlation with systolic and diastolic blood pressure.
Isra Med J Jan ;4(4):219-25.

OBJECTIVE: To evaluate serum renin levels in association with systolic and diastolic blood pressure in hypertensive patients. STUDY DESIGN: Case controlled study PLACE AND DURATION: The study was carried out at the Biochemistry Department of Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Centre, Karachi from June 2006 to July 2007. METERIAL and METHODS: A total of seventy-five subjects were included, out of which forty patients were suffering from essential hypertension and thirty-five were normal healthy subjects. The serum level of renin was measured by RIA (kit) whereas glucose, urea and creatinine by chemical methods. RESULTS: The study presented here showed a significant discordance of serum renin levels in essential hypertensive patients. Although the mean value of serum renin found significantly high (p<0.001) in hypertensive subjects but not all hypertensive have raised serum renin level but only a sub-group of 16 patients (40%) has raised level while another sub-group of 24 patients (60%) has normal or low serum level. We found a positive correlation (+0.264 and +0.218) with the height of systolic and diastolic blood pressure respectively. The glucose, urea and creatinine show non- significant results when compared to normotensives. CONCLUSION: Our findings suggest that serum renin should be measured in hypertensives because its level helps in treatment and prognosis of such patients. Present study was performed on a small sample size and provides a baseline data of renin levels in hypertensive subjects, so we recommended that same type of study should be carried out on large sample size to assess the importance of above parameters in hypertensives.

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