Nadia Saeed, Basheer Ahmad Shaikh, Qamaruddin Balouch.
Is oil of evening primrose effective for mastalgia, a comparison with danazol.
Isra Med J Jan ;4(4):235-8.

OBJECTIVE: To compare Oil of Evening Primrose and danazol,with respect to efficacy, rapidity of response and side effects in the treatment of mastalgia STUDY DESIGN: It was quasi-experimental, purposive, non-probability sampling. PLACE AND DURATION: Conducted in surgical unit I and II departments Civil Hospital Karachi over a period of one year METHODOLOGY: A total of 50 female patients with moderate to severe breast pain who visited the outpatient Surgical Department. All patients were assigned to two groups alternatively 25 in each group given Danazol, oil of evening primrose. Mastalgia in all the patients was gauged before and during the treatment according to the Cardiff, their level of mastalgia assessed and information sought about adverse effects of the drugs. RESULTS: The overall response with Danazol (CBSI 30%, CBS II 14%, CBSIII 6%) in contrast to low response with oil of evening primrose. The patient who was treated with Danazol showed distressing side effects whereas oil of evening primrose had fewer side effectsbreast pain score. All patients were seen at 8 and 12and 24 thweeks. CONCLUSION: Danazol offered good pain control but with some undesirable side effects. Danazol should be used in moderate and severe mastalgia.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com