Yuliarni Syafrita, Yanwirasti, San Machfoed M Hasan, Darwin Amir.
Comparing level of 4HNE in acute phase of ischemic stroke patients and its association with cognitive function after stroke event.
Pak J Med Res Jan ;54(3):90-3.

Background: Stroke is the leading cause of disability in the productive age, not only because of physical disability, but also due to impaired cognitive function following a stroke event. Brain damage-related stroke can be triggered by increasing the level of free radicals. 4HNE is the main and most toxic product that is released from free radical attack on polyunsaturated fatty acids. Objectives: To determine plasma level of 4HNE in patients recovering from acute phase of stroke and these with normal subjects and calculate its relationship with cognitive function after 3 months of stroke event. Patients and Methods: Eighty four patients suffering from ischemic stroke and 42 normal subjects (controls) were studied. In patients plasma 4HNE was measured between 24-72 hours of stroke and cognitive function was examined using MoCA-Ina after 3 months of stroke. Results: Plasma 4HNE was 2.5-fold increased in patients than controls (p < 0.05). The elevation was found in patients having cognitive impairment as compared to those who did not have cognitive impairment, but this was not statistically significant and no relationship was found between plasma 4HNE level and cognitive impairment after stroke. Cognitive impairment at three months after stroke was found in 56% cases. Conclusion: Elevation of plasma 4HNE was seen in acute phase of stroke but it was not associated with impaired cognitive function

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