Hurtamina Khan, Sameer Qureshi, Atif Hafeez Siddiqui, Sm Tariq Rafi.
Retrospective stuty of 356 cases of nasopharyngeal angiofi broma reported at Jinnah Postgraduate Medical Centre (JPMC) Karachi.
Pak J Surg Jan ;30(4):331-5.

Objective: To determine the incidence and management of Nasopharyngeal angiofi broma at JPMC, Karachi from 1981-2011. Design: Descriptive, Retrospective study. Subjects and method: Th e study was conducted at JPMC, from 1981-2011(30 years). Th e data includes age of patients, gender, clinical presentation, staging, mode of treatment, status of pre-op embolization, surgical procedures performed and recurrence rate. Results: Total number of cases were 356. Males were, 352 and females were 04. Minimum age was 13 years and maximum was 36 years and median age was 17.5 years. According to stage they were 39% Stage II, were 31% stage III, 08% stage IVa and were 02% stage IVb. Geographically, 48% were from hot/desert areas and 52%were from cold/high altitude areas. Commonest symptom was nasal obstruction, presnet in 98% patients and in 75% it was unilateral. Epistaxis was present in 70%. Surgical excision was performed in 349 cases while radiotherapy was done in 07 patients of stage IVb. Embolization was done in 278 patients while 78 patients were not embolized due to non availability of the facility earlier. Surgical approach commonly adopted was lateral rhinotomy in 277 patients. Midfacial degloving was performed in 30 patients, endoscopic excision was done in 13 patients and transpalatal rout was chosen in 29 patients. Recurrence was seen in 7.8% (n=28) cases. Follow-up was done aft er 03 months and 06 months and every year for the next 05 years. Conclusion: Th is is a common vascular tumour in Pakistan. Reported from both hot and cold areas. Nasopharyngeal angiofi broma is rare in females but 04 were reported and their genetic analysis was done. Before preoperative embolization era, recurrence was uncommon but more blood transfusion was required. Aft er preoperative embolization the recurrence has increased but blood transfusion has reduced. Earlier patients presented in late stage but now they present usually by stage II & III.

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