Nazir Ahmad, Razia Mehboob.
Cervical intra-epithelial neoplasia recent trends in diagnosis and management.
Pak J Med Res Jan ;41(2):43-5.

A study was carried out with a view to provide the facility of cervical screening in Gynae OPD at Nishtar Hospital, Multan and to detect and manage pre-malignant lesion of the cervix at an earlier stage. Cervical smear was taken from 526 women of 20-65 years age group attending Gynae OPD. 313 smears (59.50%) were reported to be normal, 159 (30.22%) inflammatory; 13 (2.47%) mild dykaryosis, 10 (1.90%) moderate and 2 (0.38%) severe dyskaryosis. 29 cases were considered inadequate because of blood stained specimen or artifacts. Patients with mild dyskaryosis were advised careful follow-up and repeat cervical smear after 6 months. Colposcopy was performed in 12 cases of moderate to severe dyskaryosis and 10 patients had abnormal aceto-white areas and directed punch biopsy was taken from all these cases. Histopathology of the cervical tissue revealed CIN-2 in 8 cases of moderate dyskaryosis and CIN-3 in 2 cases of severe dyskaryosis. Patients with CIN-2 were managed by local destruction with electro-cautery and followed up for 2 years. Women with CIN-3 were treated by abdominal hysterectomy. Cervical intra-epithelial neoplasia – a pre-malignant condition can be treated effectively if diagnosed at an earlier stage.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com