Neki N S, Ankur Jain.
Carbimazole induced cholestatic hepatitis in grave’s disease - a case report.
Ann King Edward Med Uni Jan ;22(2):144-6.

Grave’s disease is the most common cause of hyper-thyroidism. Antithyroid drugs are usually well tolera-ted in majority of patients but serious side effects in the form of allergy, agranulocytosis, aplastic anaemia, vasculitis, hepatitis etc occur in 3 – 12% of treated pat-ients. Carbimazole is extensively used as the drug of choice except in pregnancy, where propylthiouracil is preferred. We report a case of 35 year old female pat-ient with Grave’s disease, who developed cholestatic jaundice following administration of carbimazole for 2 months. Symptoms and laboratory abnormalities sub-sided on withdrawal of carbimazole and Grave’s thy-rotoxicosis was managed with propranolol and propyl-thiouracil.

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