Nisar Ahmed, Saqib Saleem Afridi, Mohammad Ziaulhaq, Mahmud Aurgangzeb, Muhammad Muslim, Mohammad Zarin.
Role of prophylactic antibiotics in laparoscopic cholecystectomy in the prevention of skin and skin structure infections.
Pak J Surg Jan ;28(1):21-4.

Objective: To compare the frequency of skin and skin structure infections in patients undergoing laparoscopic cholecystectomy with and without prophylactic antibiotics. Study Design: Randomized controlled Trial Place and Duration of Study: Surgical B Unit, Department of Surgery, Khyber Teaching Hospital, Peshawar Methodology: A total number of 144 patients randomized into two equal groups; A and B were included. Group A received prophylactic cefuroxime 1.5 g diluted into 10 ml solution while Group B received 10 ml normal saline before the induction of anaesthesia, no antibiotics were administered thereaft er to either group. Th e frequency of skin and skin structure infection (SSI) were compared in both groups. Results: In Group A 3(4.1%) patients developed skin and skin structure infection, while in Group B 2(2.7%) patients developed skin and skin structure infection. Th e diff erence between the two groups was not statistically signifi cant (p=1.000). Conclusion: Administration of prophylactic antibiotics does not reduce the frequency of skin and skin structure infections in patients undergoing laparoscopic cholecystectomy.

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