Khalid Niaz, Shahina Hakro, Amarlal Ghurbakhshani, Abdul Qudoos, Shah Murad.
Alpha-tocopherol and Ziziphus Jujuba as Mild to Moderate Hypolipidemic Agents.
Ann Jinnah Sindh Med Uni Jan ;2(2):60-3.

High plasma lipids, especially LDL-cholesterol, and low HDL-cholesterol in presence of or frequent formation of free radicals in various metabolic pathways in human body may lead to development of atherogenesis, CAD. Isomer of alpha tocopherol has antioxidant effects like other hypolipidemic drugs used in allopathy. Ziziphus Jujuba is medicinal plant having hypolipidemic potential. We conducted study on comparison of hypolipidemic effects of these two agents. Study was placebo-controlled conducted in Jinnah Hospital, Lahore from December 2015 to February 2016. Ninety hyperlipidemic patients were divided in three equal groups including 30 patients in each group. Their base line LDL-cholesterol and HDL-cholesterol was determined and kept in their personal file. Group-1 was on placebo, Group-2 was on Vitamin E 400 mg twice daily for two months. Group-3 was on half Kg Jujuba per day for two months. After two months therapy their post treatment LDL and HDL-cholesterol was determined. When analyzed statistically, results showed non-significant effects of herbal fruit/drug Jujube on HDL-cholesterol but significant role on LDL-cholesterol reduction. While vitamin E has highly significant reduction potential in LDL-cholesterol and significant effects on HDL-cholesterol with p-value <0.01. We concluded from the study that Z. Jujuba has antioxidant potential by lowering LDL-cholesterol in human plasma. But This effect is not comparable with hypolipidemic effects of Vitamin E as it also increases good cholesterol i.e. HDL-cholesterol.

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