Muhammad Saeed Afridi, Asif Mushtaq, Imran Khan, Ashfaq Ahmad, Javed Ahmad, Nouman Ahmad.
A Comparison of two Priming solutions: Ringer’s lactate Versus Hydroxyethyl Starch Solution.
J Cardiovascular Dis Jan ;12(2):42-5.

ObJECTIVE: To compare the effect on hemoglobin (Hb), blood sugar random (BSR), renal function, liver function and bleeding in ringer’s lactate versus hydroxyethyl starch (HES) solution as a priming solution. MATERIAL AND METHODS: A prospective comparative study was conducted at the Department of Cardiac Surgery, Punjab Institute of Cardiology, Lahore, from October 2012 to December 2012. The total number of patients included in the study was 100. Patients were categorized into group 1 (Ringer solution) and Group 2 (HES 130-0.4) with 50 patients in each group. All the patients underwent coronary artery bypass grafting (CABG). Patients having heart diseases other than coronary artery disease and patients with renal failure were excluded from the study. Data was analyzed using SPSS (Statistical Package for Social Sciences). P-value <0.05 was considered significant. RESULTS: Out of 100 patients, 38% were female and 62% were male. The mean age of the patients was 44.81±18.319 years. There was an insignificant difference between risk factors in both groups (P-value >0.05). The outcome in terms of blood sugar random (BSR) was significant (P-value <0.05) in hydroxy ethyl starch (HES) group as compared to ringer lactate group whereas the effect on Hb, liver function, renal function and PT, APTT were insignificant (P-value>0.05). CONCLUSION: Both Ringer’s Lactate and HES solution lead to the same results in terms of Hb, liver function tests, renal function tests and PT, APTT when used as priming solutions in cardiopulmonary bypass in patients undergoing CABG, whereas BSR increases in HES group. KEY WORDS: Priming solutions, Comparison, Ringer’s Lactate, HES Solution.

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