Rasheed N, Amin N, Ghaznavi S.
Association of serum uric acid with level of blood pressure in type 2 diabetic patients.
Biomedica Jan ;32(2):111-4.

Background and Objectives: Diabetes mellitus (DM) is a chronic disease characterized by insulin deficiency or peripheral resistance resulting in hyperglycemia. Hyperuricemia has been reported with increased risk of renal insufficiency. The objective of the study was to determine the association of uric acid with blood pressure in type 2 diabetic patients. Methods: In this study eighty patients with type 2 diabetes mellitus were included. No patient had history of gout or history of using antihypertensive or uric acid lowering drugs. HbA1c was performed on Hemoglobin – Testing System (D-10-Biored Laboratories). Serum uric acid (UA), serum creatinine and plasma glucose were measured on fully automated chemistry analyzer (Metrolab – 2300). Results: The study population consisted of 80 subjects, among them 32 (40%) were male and 48 (60%) were female. Among 80 subjects, the age limit started from 50 years to 68 years with mean of 58.16 ±. Mean HbA1c level was 7.63 ± 1.6, mean uric acid level 5.86 ± 0.97 and mean creatinine level was 0.86 ± 0.20. Mean systolic and diastolic blood pressure were 124 ± 11.78 and 82.50 ± 8.49 respectively. Uric acid levels are correlated with blood pressure (systolic and diastolic) in diabetic patients. Conclusion: The present study demonstrated a strong correlation between serum uric acid and systolic and diastolic blood pressure levels in type 2 diabetic patients.

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