Maimoona Khan, Shahdab Ahmed Butt.
Effect of Caffeine and Vitamin D3on Body Weight of Balb/CMice.
J Rawal Med Coll Jan ;20(4):320-2.

Background:To evaluate effect of caffeine and vitamin D3on body weight of BALB/c mice.Methods:In this experimental study thirty BALB/c mice, three weeks old with average weight 12-14 g were taken and divided into three groups with 10 mice (5 male, 5 female) in each group. The control group G1was given normal diet prepared at National Institute of Health Islamabad with liberal water intake. Each animal in experimental group G2was given 10mg of caffeine per100g body weight on alternate day, three days in a week by oral gavage for 60 days. All animals of G3were given caffeine 10mg/100g body weight on alternate day, three days a week and vitamin D30.1μg per day by oral gavage for 60 days. The effect of caffeine and vitamin D3was assessed by measuring the body weight of the mice at the end of the experiment.Results:Mean final body weight of mice of control groupG1was31.2 ± 1.932 g while the mean final body weight of experimental groups G2and G3was found to be 27.1 ± 2.025 g and 29.2 ± 2.098 g . Mean final body weight of mice of experimental group G2was less as compared to control group G1and experimental group G3.Conclusion:The body weight of the mice was reduced due to caffeine consumption while vitamin D3administration ameliorated the deleterious effect of caffeine on the body weight.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com