Fatima Khanum, Amna Khanum, Suhaib Ahmad.
The jak2 v617 mutation triggers erythropoiesis and patients present with good hemoglobin level in idiopathic myelofibrosis (IMF).
Esculapio J Services Inst Med Sci Jan ;9(1):15-6.

Objective: To document the impact of JAK2 mutation on hemoglobin (Hb) level in patients with IMF. Material & Methods: Thirty five patients were studied out of which 19 were JAK2 positive and 16 were JAK2 negative. Sample collection technique was purposive non-probability sampling. Variations were observed among the studied JAK2 positive and JAK2 negative patients regarding hemoglobin level. Results: In JAK2 positive and negative patients mean hemoglobin level was 10.6g/dl and 8.6g/dl respectively (p=0.29). Conclusion: Due to the better hemoglobin level, patients with JAK2 mutation have less transfusion requirements and are partially protected against severe anemias compared to patients with no mutation.

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