Samia Sadiq, Adeel Ahmad, Maham Javed.
Association of Vitamin D Deficiency with Ischemic Cardiomyopathy.
J Cardiovascular Dis Jan ;14(1):16-8.

OBJECTIVE: To enhance further investigation in relation to vitamin D deficiency and its association with ischemic cardiomyopathy. From the past studies it is reported that vitamin D deficiency is coupled with variety of diseases, including ischemic heart diseases and other cardiovascular disorders. MATERIAL & METHODS: In this case control study, 1135 ICMP patients and 1135 controls were admitted in Jinnah hospital Lahore from January to August, 2017. 25-Hydroxyvitamin D (25(OH)D) quantification of every patient serum was measured with diasorin radioimmunoassay method. RESULTS: In this study, the mean age of patients in case group was 58.91±7.36years while mean age of control group was 59.67±10.23years. There were 517 males and 618 females in case group while there were 522 males and 613 females in control group. Among cases, vitamin D deficiency was observed in 79% patients while among controls, vitamin D deficiency was observed in 77.5% patients. There was although high risk of ICMP due to vitamin D deficiency i.e. OR=1.092 (95% CI: 0.8945, 1.333), but it was statistically insignificant (p 0.38). CONCLUSION: Vitamin D deficiency may increases the risk of ICMP by promoting ischemia and weakness of cardiac muscles. But further studies on larger scale are required to establish its causal relationship.

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