Muhammad Asif.
Variation in Lipid Status In Chronic Kidney Disease Patients On Dialysis.
J Saidu Med Col Jan ;8(1):3-5.

BACKGROUND: Impaired renal function is associated with cardiovascular disease and is a major cause of morbidity and mortality in cardiac patients. Dyslipidemia has been established as a well-known traditional risk factor for cardiovascular disease in the general population and it is well known that patients with chronic kidney disease exhibit significant alterations in lipoprotein metabolism. OBJECTIVE: To determine variability in lipid parameters in chronic kidney disease patients on dialysis. MATERIAL & METHOD: A total of 100 subjects (both male and female) were taken for the study. 50 of them were apparently healthy, while the remaining 50 were chronic kidney disease patients on dialysis. The levels of triglyceride, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein- cholesterol and very low density lipoprotein cholesterol were estimated using enzymatic methods. Their cardiovascular risk indices (TC/HDL-C and LDL-C/HDL-C) were also determined. RESULTS: The results indicated that all the parameters were significantly (p<0.05) altered in both sexes when compared with the control group. The cardiovascular risk indices, TC/HDL-C and LDL-C/HDL-C of the chronic kidney disease patients were higher than those of the control group. CONCLUSION: Chronic kidney disease patients on dialysis are at risk of developing cardiovascular disease. Key Words: Chronic kidney disease, lipid profile, cardiovascular disease.

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