Yousaf Jamal Mahsood, Hussain Ahmad, Muhammad Naeem, Irfan Ullah, Saima Farooq, Muhammad Sadiq, Farah Akhtar.
Trabeculectomy versus Combined Trabeculectomy and Cataract Surgery in Pseudoexfoliation Glaucoma.
Al-Shifa J Ophthalmol Jan ;12(3):131-4.

Aims: To compare the success rate of trabeculectomy versus combined trabeculectomy plus cataract extraction augmented with 5-Fluorouracil in pseudoexfoliation glaucoma. Study Design: Case control study. Methods: Past records of patients with pseudoexfoliation glaucoma (PXF-G) who had undergone trabeculectomy with 5-Fluorouracuil (5-FU) (Group 1) or combined trabeculectomy and cataract extraction (Group 2) with5-FU were obtained and analyzed. All those patients were included who were stable for at least 6 months before entering into the study. To avoid bias in the results, those patients were excluded who had intraoperative complications like posterior capsular rupture, vitreous loss, zonular dialysis etc. A total of 40 patients were included with 20 in each group. The primary outcome, effect on intraocular pressure (IOP), was compared between the two groups. Results: The Group 1 had significant reduction in IOP (p < 0.02) with mean pre-treatment IOP of 30.72 + 7.44 mm of Hg to final IOP of 15.30 + 5.43 mm of Hg. Similarly, Group 2 had also significant reduction in IOP (p < 0.032) with mean pre-treatment IOP of 31.20 + 7.68 mm of Hg to final IOP of 16.01 + 5.55 mm of Hg. When both groups were compared for final IOP, it was not significant (p < 0.3). The success rate of group 1 was 83.5 + 5.5% while that of group 2 was 80.4 + 4.3 %. Conclusion: Both techniques achieved good IOP reduction and combined trabeculectomy plus cataract surgery with 5-FUis a safe option in patients with PXF-G and cataract.

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