Naima Javed, Saadia Shahzad Alam, Habib Subhani, Shoaib Akhtar, Abdul Hameed Khan.
Evaluation of Analgesic activity of Mucuna pruriens Linn. Seeds.
Proceeding Shaikh Zayed Postgrad Med Comp Jan ;22(1):69-72.

Pain is one of the most common symptom though having protective role, but usually unpleasant. So far medicines available for its management are not only partly effective but having significant adverse effects. Purpose of study: To evaluate the analgesic activity of Mucuna pruriens Linn. seed powder. Materials and Methods: This study has been carried out in five groups of albino mice, having 8 animals each. Three different doses of Mucuna pruriens Linn seed powder has been given to three groups and analgesic activity has been compared with the other two groups, standard and control. Formalin paw licking test has been used to evaluate the analgesic activity and decrease in the number of lickings in 30 minutes after formalin injection has been interpreted as analgesic activity. Results: Mucuna pruriens Linn Seeds showed significant analgesic activity as depicted by decrease in number of lickings in 30 minutes period i.e, seeds in lgm/kg group, 32.625 ± 6.13 and group receiving seeds 2gm/kg 24.25 ± 6.64. Group receiving 3gm/kg seed powder is 21.0 ± 8.48 which is significantly less than the control which is 44.125 ± 5.88 (p < 0.05). Conclusion: Mucuna pruriens seeds powder showed significant analgesic activity in all three groups and activity increases with increasing the dose of the seed powder.

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