Naima Javed, Saadia Shahzad Alam, Habib Subhani, Oaib Akhtar M Shoaib, Abdul Hameed Khan.
Evaluation of Anti-inflammatory Activity of Mucuna pruriens Linn. Seeds.
Proceeding Shaikh Zayed Postgrad Med Comp Jan ;24(1):97-102.

Inflammation is associated with pathophysiology of various clinical conditions like arthritis, gout and cancer. Numbers of drugs are being used to treat inflammation but they are partly effective and have significant adverse effect profile. Mucuna pruriens is traditionally used to relieve fever, pain and inflammation. Purpose of the study: To evaluate the anti-inflammatory activity of Mucuna pruriens Linn. seed powder. Materials and Methods: This study has been carried out in five groups of albino mice, having eight animals each. Three different doses of Mucuna pruriens Linn seed powder has been given to three groups and anti-inflammatory activity has been compared with the other two groups, standard and control. Carrageenan-induced paw edema has been used to evaluate the anti-inflammatory activity and decrease in paw edema after 1, 2, 3, and 4 hours have been interpreted as anti-inflammatory activity. Results: Mucuna pruriens Linn seed powder showed significant anti-inflammatory activity in all three groups as depicted by decrease in edema after 1, 2, 3, and 4-hours (p < 0.05).Conclusion: Mucuna pruriens seed powder showed significant anti-inflammatory activity in all three groups of mice and activity increases with increasing the dose of seed powder.

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