Qurrat-ul Aen Inam.
Injected Leptin Improves Performance of Rats, Relationship with Circulating Corticosterone and Serotonin.
Ann Jinnah Sindh Med Uni Jan ;3(2):59-63.

Objective: To monitor the changes resulting from injecting leptin into rats on their spatial memory and serum corticosterone, serotonin, and tryptophan secretion Methodology: Animals were trained in Morris water maze. Immediately after training, animals were injected 0.1 and 0.5 mg/kg doses of leptin intraperitoneally. Memory was assessed at 2 and 24 hours after administration. Results: Results of Morris water maze test showed enhanced memory acquisition and retention. This indicates that injected doses of 0.1 mg/kg and 0.5 mg/kg leptin effectively decreased the collective food intake at 24hr period in freely fed rats. Leptin injected animals showed increased serum serotonin level and decreased tryptophan level. Administration of a lower dose of leptin showed increased level of corticosterone. Conclusion: The results indicate a correlation between levels of leptin and memory enhancement which also affects serotonin, corticosterone, and tryptophan levels in body. Key words: Leptin, Cognition, Peripheral serotonin

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