Fareena Khalil Ahmed, Abdul Shakoor Memoon, Intesar Burney.
Correlation Between Serum Leptin and Serum Testosterone in Male Infertility Patients at a Tertiary Care Hospital of Karachi.
Ann Jinnah Sindh Med Uni Jan ;3(2):64-9.

Objective: To study the correlation between serum leptin and serum testosterone in male infertility patients presenting in a tertiary care hospital of Karachi Methodology: This case control study was conducted in the Department of Physiology, Basic Medical Sciences Institute (BMSI) in collaboration with Reproductive Health Sciences, (Male Infertility Clinic) at the Jinnah Postgraduate Medical Centre (JPMC), Karachi. Samples of 100 infertile married males was divided into two groups. Group A as a control group had 25 subjects. Group B as a case group had 75 subjects, which were subdivided into three groups of infertile males i.e. (B1=Azoospermia, B2=Oligospermia, and B3=others). The ages, Body Mass Index (BMI), serum leptin and serum testosterone were measured. Serum testosterone and serum leptin were quantitatively measured by enzyme immunoassay. Result: The BMI examination of the control and case groups showed significant association across all the four groups with the p<0.05. In serum leptin and serum testosterone levels, significant associations were found between control and cases across all the four groups i.e. p<0.05. Conclusion: This study showed a strong inverse correlation between serum leptin levels, Body Mass Index (BMI), and serum testosterone levels. This suggests that BMI and hormone levels contribute significantly to male infertility. Key words: Serum leptin, serum testosterone, male infertility, correlation

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