Khalid Fahim Yasin, Muhammad Sabir, Shakila Yasmin, Murad Khan.
Protective role of vitamin B6 in Gentamicin Nephrotoxicity.
Pak J Med Res Jan ;41(4):148-51.

The use of gentamicin in daily clinical practice is very common. It`s well known toxic side effect is mainly on kidneys. This antibiotic causes lipid peroxidation as an ultimate event in its nephrotoxic effect, which explains why Gentamicin induced nephrotoxicity is not affected by many powerful antioxidants like vita A., C., and E. and when tried with agents like Nitrendipine also. Gentamicin toxic effect elicits itself as an acute renal cortical tubular necrosis. It has recently been established that in rabbits, there occurs a decrease in pyridoxal 5 phosphate (a coenzyme of Vitamin 136) levels when gentamicin is given even in therapeutic doses.The present study was, therefore, designed as an endeavor to ascertain and establish the role (if any) of vitamin B6 supplementation for the protection/elimination of the nephrotoxic effect of gentamicin. For this purpose, 28 male albino rats were used by making four groups with seven animals in each. Group A, kept as control Group. B given vit. B6, group C administered Gentamicin and D group given Gentamicin + B6, I/P, daily for 10 consective days. Animals were sacrificed after 10 days, their kidneys were removed, divided, fixed and evaluated structurally at histological levels under light microscope. The morphological changes in the structure of kidneys of group C animals (nephrotoxic group) were analyzed and compared with other groups i.e. A, B and D to reach the conclusion that the renal toxicity produced by Gentamicin could be inhibited effectively by simultaneous vitamin B6 treatment.

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