Nasir Khokhar.
Association of chronic hepatitis C virus infection and diabetes mellitus.
Pak J Med Res Jan ;41(4):155-8.

Objective: To determine if there was an association of chronic hepatitis C virus infection with diabetes mellitus Methods: Four hundred and forty three patients of chronic hepatitis C virus infection were analyzed retrospectively. These had HCV RNA positive by PCR. Some of these had liver biopsies and quantitative viral loads and hepatitis C serotype performed. Diabetes mellitus was considered to be present if patients were already on diabetes treatment or fasting or random blood sugar indicated diabetes mellitus according to standard criteria. Results: There were 244 males and 199 females patients. Ages ranged from 15 years to 71 years but most were between 21-70. Out of 443 patients, 81 patients (18.28 %) had diabetes mellitus. There were 411 patients with chronic hepatitis C and out of these 71 (17.27 %) had diabetes mellitus. Thirty-two patients had biopsy proven cirrhosis and 10 of these patients (31.25 %) had diabetes mellitus. Out of 71 patients of diabetes with chronic hepatitis C virus infection, 60 (84.5 %) had non-insulin dependent diabetes mellitus. Ten patients who had biopsy proven cirrhosis all had non-insulin dependent diabetes mellitus. Conclusion: Patient with chronic hepatitis C virus infection and cirrhosis secondary to hepatitis C virus infection have strong association with diabetes mellitus and great majority of them are non-insulin dependent diabetics. Key Words: Hepatitis C, Diabetes Mellitus

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com