Sohail Mahmood Ch, Bushra Lali.
Use of Calcium Dobesilate and Norethisterone in Treatment of Menorrhagia of Dysfunctional Uterine Bleeding Origin.
J Surg Pak Jan ;22(2):65-7.

Objective: To find the success rate of calcium dobesilate and norethisterone in treatment of menorrhagia of dysfunctional uterine bleeding (DUB) origin. Study design: Descriptive case series. Place & Duration of study: Department of Obstetrics & Gynaecology, Bahawal Victoria Hospital / Quaid-e-Azam Medical College Bahawalpur, from December 2013 to December 2016. Methodology: Patients with dysfunctional uterine bleeding were included in this study. They were divided into two groups. Group A was given calcium dobesilate and Group B was given norethisterone for menorrhagia of DUB. The outcome in terms of resolution of symptoms was noted at follow up on 8,10 and 12 weeks in outpatient department. Results: A total of 600 patients of 19 year to 35 year of age were enrolled. The success rate in terms of cessation of bleeding was 83.3% in group A. This was observed within 3-5 days of starting treatment and patients remained symptoms free for the next 10-12 weeks after discontinuation of the medicine. Success rate of 98% was observed in group B however on withdrawal of medicine bleeding started again. More side effects were also observed in group B. Conclusions: Arrest of bleeding in patients with menorrhagia of DUB was more frequently noted in group B where norethisterone was used, however, it recurred on withdrawal of medicine. More side effects were also observed in group B. In group A though success rate was low but no withdrawal bleeding occurred after cessation of medicine.

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