Tasleem Arif, Mohammad Adil, Syed Suhail Amin.
Neurofibromatosis-1 and zosteriform nevus spilus: a very rare clinical coexistence.
J Pak Assoc Derma Jan ;27(1):97-8.

Sir, neurofibromatosis-1 (NF-1), or von Recklinghausen’s disease is an autosomal dominantly inherited genodermatosis that presents with multisystem involvement predominantly the skin, eyes, brain and bone. About half of the cases occur due to sporadic mutations. NF-1 is associated with several pigmented cutaneous anomalies like café-au-lait macules, axillary freckling, malignant melanoma and other melanocytic nevi.1 The speckled and lentiginous nevus, also referred to as nevus spilus, is an uncommon congenital melanocytic disease that has a café-au-lait like hyperpigmented background, on which dark brown nevi are seen. We describe a patient of NF-1 with zosteriform nevus spilus. To the best of our knowledge, this rare coexistence has not yet been reported in literature.

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