Muhammad Saeed, Muhammad Ali Kashif, Asim Shehzad.
Frequency of Subclinical Hypothyroidism in Chronic Kidney Disease.
J Islamic Int Med Coll Jan ;12(3):144-7.

Objective: To determine the frequency of Subclinical hypothyroidism in patients with chronic kidney disease. Study Design: Cross sectional study. th th Place and Duration of Study: Department of Medicine Military Hospital Rawalpindi, from 20 July 2015 to 05 January 2016. Materials and Methods: In this study 250 patients were included, 50 patients for each stage of chronic kidney disease (CKD) starting from stage II to stage V and 50 peoples were from normal control group. Serum Creatinine, Thyroid Stimulating hormone (TSH) and Free T4 (thyroxine) were measured. Data was analyzed by SPSS version 17. The quantitative variables like age, free T4 and TSH was presented in mean and standard deviation for each group. Qualitative variables such as sex and presence or absence of subclinical hypothyroidism was reported as frequencies percentages for each group. Comparison of TSH level in four stages of CKD and control group was performed by using Kruskal Wallis ANOVA. Mann Whitening U test was used for Post Hoc analysis if required. Comparison of frequency of Subclinical hypothyroidism among groups was performed by using Chi-Square likelihood ratio. P value lower than 0.05 was taken statistically significant. Results: Frequency of Subclinical hypothyroidism was 04 % in normal control group. Frequency of Subclinical hypothyroidism was 06%,10%,12% and 16% in stage II, III, IV and V respectively. Frequency of Subclinical hypothyroidism was increases with decrease of GFR. Frequency of Subclinical hypothyroidism was slightly increased preponderance in female as compared to male. Conclusion: Frequency of subclinical hypothyroidism is higher in CKD patients than normal population, but it is statistically not significant.

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